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Subject: Hallucinations in Advanced PD (AAN 2004) Date: 5/18/2004 E-MOVE reports from the American Academy of Neurology, San Francisco April 25-30, 2004. Page (A), session (S) and poster (P) numbers are from Neurology 2004;62(7), Suppl 5Visual hallucinations and sleep disorders in Parkinson’s disease: Six-year prospective longitudinal study CG Goetz, J Wuu, LM Curgian, S Leurgans P04.146, A333 Sleep disorders and hallucinations follow different patterns of progression in PD, according to this study. Eighty-nine patients with PD with either normal cognition, sleep fragmentation, vivid dreams/nightmares, hallucinations with insight, or hallucinations without insight, were assessed over 6 years with the Pittsburgh Sleep Quality Index and Rush Hallucination Inventory. Odds of becoming a hallucinator increased by 1.4 at each assessment (6 months, 18 months, 4 years, 6 years). Presence of vivid dreams/nightmares correlated with hallucination occurrence and severity. Sleep disorders did not increase in severity during follow-up. “The persistent and progressive character of hallucinations contrasts with the fluctuating and overall non-progressive course of sleep abnormalities,” the authors conclude. Risk Factors for Hallucinations in Parkinson’s disease R Inzelberg, D Paleacu, E Schechtman, R Carasso, P Nisipeanu P04.147, A333-334 Thirty-five percent of 171 PD patients (mean age 73, levodopa treatment duration 5.5 years) experience hallucinations, as determined by questionnaire. Compared to non-hallucinating patients, hallucinators were more likely to have dementia (49% vs. 19%), and have a family history of dementia (16% vs. 3%). Family history of tremor or PD was not associated with risk for hallucinations. The authors suggest that a family history of dementia “is a novel and prominent risk factor for hallucinations in PD, which should be sought for in patient history.” [end] E-MOVE Editor: Richard Robinson, NASW, WE MOVE
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