APOE-4 Increases Risk, Lowers Age of Onset of PD (AAN 2003)

Subject: APOE-4 Increases Risk, Lowers Age of Onset of PD (AAN 2003)

Date: 4/11/2003

E-MOVE reports from the 55th Annual Meeting of the American Academy of Neurology, held in Honolulu March 29-April 5 2003. Poster numbers, session numbers, and pages are from Neurology 2003;60.

Apolipoprotein E controls risk and age at onset of Parkinson disease
YJ Li, ER Martin, WK Scott, JL Haines, MA Nance, JP Hubble, BC Hiner, J Jankovic, CG Goetz, GW Small, RA Gibson, LT Middleton, JM Vance
P02.077; A127-A128

The APOE-4 allele increases the risk and lowers the age of onset for Parkinson’s disease, according to this study.

Individuals from 658 families with at least one member with either sporadic or familial PD were genotyped. PD risk was significantly increased by APOE-4 in all PD families, as well as in subsets of late-onset PD and familial PD. Individuals with 4/4 alleles had an approximately 1 year earlier onset than those with 3/4.

A previous E-MOVE report on age-of-onset genes is archived at http://www.wemove.org/emove/article.asp?ID=423

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E-MOVE meeting reports are funded in part by unrestricted educational grants from these sponsors:
Gold Level: Bertek Pharmaceuticals
Silver Level: Amarin Pharmaceuticals
Bronze Level: Allergan Inc., Procter & Gamble Pharmaceuticals, Schwarz Pharma

E-MOVE Editor: Richard Robinson, NASW, WE MOVE