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Subject: Long-Duration Improvement from STN DBS (AAN 2003) Date: 4/2/2003 E-MOVE reports from the 55th Annual Meeting of the American Academy of Neurology, held in Honolulu March 29-April 5 2003. Poster numbers, session numbers, and pages are from Neurology 2003;60.Bilateral subthalamic nucleus deep brain stimulation (B-STN DBS) changes the expected course of Parkinson's disease H Bronte-Stewart, T Courtney, K Maguire, H Shaw, G Fujikami, G Heit P02.059, A121 STN DBS patients remain improved versus baseline for prolonged periods after discontinuation of medication and stimulation, according to this study. Nineteen bilateral STN DBS patients underwent motor and postural instability testing, at baseline and 6 and 12 months post-surgery. Post-operative evaluation occurred in the on medication on stimulation states, as well as off/on (off medication for 12-24 hours), and off/off (off medications 29-47 hours, off stimulation 17-23 hours). All post-operative measures were better than the preoperative counterparts, despite 6-12 months disease progression. Pre-op off was 40.4, versus 32.3 and 37.5 off/off at 6 and 12 months (p<0.05 for 6 months). Pre-op on was 15.4, versus approximately 8 for both off/on and on/on at 6 and 12 months. Postural instability improved by 100% and 75% at 6 and 12 months (off vs. off/on). The authors conclude the maintenance of benefit in the absence of stimulation may represent either a prolonged therapeutic effect or modulation of disease progression. --- E-MOVE meeting reports are funded in part by unrestricted educational grants from these sponsors: Gold Level: Bertek Pharmaceuticals Silver Level: Amarin Pharmaceuticals Bronze Level: Allergan Inc., Schwarz Pharma E-MOVE Editor: Richard Robinson, NASW, WE MOVE
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