PD: APOE genotype, familial vs. sporadic features (AAN report)

Subject: PD: APOE genotype, familial vs. sporadic features (AAN report)

Date: 4/23/1999

E-MOVE presents news from the scientific platform and poster sessions at the American Academy of Neurology annual meeting in Toronto, 17-24 April 1999.

The apolipoprotein E genotype in Parkinson's disease with and without dementia: The Rotterdam study
SB Harhangi, MC de Rijk, CM van Duijn, A Hofman, MMB Breteler
Neurology 1999;52 (Suppl 2):A12-13

The apolipoprotein alleles E2 and E4 are associated with an increased risk of PD with dementia, according to this prospective, population-based study.

APOE genotyping was performed on 104 PD patients (25 with dementia, 79 without) and 5454 nonparkinsonian individuals in this group of 6969 participants. In all PD-dementia cases, onset of PD preceded onset of dementia. Genotyping was done without knowledge of clinical status.

Neither the E2 nor the E4 allele was found to be associated with PD without dementia. Both E2 and E4 were associated with PD with dementia (OR=5.7 for E2, 3.7 for E4). The authors conclude "Our findings are compatible with the view that PD with and without dementia are distinct entities with a, at least partly, different pathogenesis."

Parkinson's disease: Clinical features in sibships
JP Hubble, et al.
Neurology 1999;52 (Suppl 2):A13

Study of 187 families with 2 or more siblings affected with PD shows that the clinical features of PD closely resemble those of common sporadic PD, including prevalence of tremor, levodopa responsiveness, and slight male predominance.

E-MOVE Editor: Richard Robinson, NASW, WE MOVE

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