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Subject: BTX-B for Blepharospasm (Toxins 2002) Date: 6/27/2002 E-MOVE reports from the International Conference 2002: Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins. Poster (P) and page (R) numbers are from Naunyn Schmiederberg's Archives of Pharmacology 2002;365(supplement 2).Botulinum neurotoxin B in blepharospasm C Colosimo, M Chianese, M Giovanelli, F Contarino, AR Bentivoglio P30; R16 BTX-B is an effective treatment for blepharospasm, according to this report. Fourteen patients with blepharospasm with moderate-to-good response to BTX-A received 2500 U Neurobloc (Myobloc) in 4-5 sites per side. Fahn-Marsden rating fell from a mean of 1.9 to 1.1 (p<0.001), with a mean duration of 44.6 days. Patients reported a mean 35% improvement. Eleven patients had transient burning pain on injection; one patient had local edema at the injection site. The authors state, "The time course and magnitude of the improvement in our study are similar to those reported in trials with BTX-A." ---- 2002 E-MOVE conference reports are made possible in part through unrestricted educational grants from Elan Pharmaceuticals, GlaxoSmithKline, and Pharmacia Corporation. E-MOVE Editor: Richard Robinson, NASW, WE MOVE
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