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Subject: DysportŪ Dosing Studies Date: 11/17/1999 E-MOVE reports live from International Conference 1999: Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, 15-18 November, 1999 in Orlando, Florida. This conference is sponsored by WE MOVE in conjunction with the Movement Disorder Society, and funded in part by unrestricted grants from Allergan, Athena Neurosciences, and Ipsen Ltd. Poster abstracts are scheduled to appear in a future issue of Movement Disorders.1. Standardized dose of 500 MU of DysportŪ for cervical dystonia: Results of a prospective, randomized, double-blind, placebo-controlled study P Kanovsky, E Ruzicka, R Jech, J Roth, P Schnider, E Auff, J Wissel, C Brenneis, W Poewe Poster 2633 Five hundred units of Dysport is effective for most patients with cervical dystonia, according to this study. Sixty-eight patients were randomized to receive either placebo or at total of 500 U Dysport into involved muscles. At week 4, Tsui scores had improved from 11.1 to 5.7 in treated patients, vs. 11.5 to 8.8 in placebo (p=0.001). Pain scores were also significantly improved for treated patients (p=0.02) . The most commonly reported adverse event was dry mouth. 2. Cervical dystonia: Successful treatment with low dose of botulinum toxin (BTX) C Machado, HB Santiago, MA Ferro Poster 2679 Cervical dystonia can be effectively treated with a low-dose, high-volume dilution of Dysport, according to this study. Sixteen patients with CD received three successive treatments with a concentration of 500 U/mL (median dose 433.3 U), followed by three treatments with a concentration of 50 U/mL (median dose 189.9 U). Patient groups did not differ in significantly in time of onset, duration of effect, or degree of improvement as measured on the Tsui scale. Patients receiving the lower dose and concentration had significantly less dysphagia and cervical weakness. The authors suggest the equivalent effect from the lower dose is a result of greater diffusion of the higher volume used with the more dilute preparation. E-MOVE Editor: Richard Robinson, NASW, WE MOVE
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